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This review aims to synthesize current literature on the stimulators and inhibitors of angiogenesis, highlighting key molecular factors involved.

Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors

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This review aims to synthesize current literature on the stimulators and inhibitors of angiogenesis, highlighting key molecular factors involved.
Comprehensive literature review on angiogenesis and its regulation.
Emphasis on growth regulatory proteins that either promote or inhibit blood vessel growth.
Discussion of specific angiogenic factors like VPF/VEGF and thrombospondin.
VEGF is identified as a primary angiogenic inducer, crucial for capillary formation.
Thrombospondin is highlighted as a significant natural inhibitor of angiogenesis.
Pathological conditions show a shift towards increased angiogenic stimulus, impacting healing and tumors.

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Review explores the balance of angiogenic stimulators and inhibitors, suggesting implications for pathological conditions.

Iruela-Arispe et al. (1997) studied this question.

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