Why the study?
Modulating the angiogenic balance represents a therapeutic route in diseases requiring either angiogenesis inhibition or activation.
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Design
Review
Angiogenesis modulation in pathology merits cautious exploration; leaves open targeted cardiovascular trials before clinical adoption.
Angiogenesis is the process of developing new blood vessels from pre-existing ones. This review summarizes the main features of physiological and pathological angiogenesis and those of angiogenesis activation and inhibition. In healthy adults, angiogenesis is absent apart from its involvement in female reproductive functions and tissue regeneration. Angiogenesis is a complex process regulated by the action of specific activators and inhibitors. In certain diseases, modulating the angiogenic balance can be a therapeutic route, either by inhibiting angiogenesis (for example in the case of tumor angiogenesis), or by trying to activate the process of new blood vessels formation, which is the goal in case of cardiac or peripheral ischemia.
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Ionescu et al. (2022) studied this question.
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