What question did this study set out to answer?

To examine the pathophysiology of tumor angiogenesis, the molecular mechanisms driving vascular normalization, and the therapeutic implications of restoring vascular integrity in cancer and nonmalignant diseases.

July 1, 2011Physiological Reviews

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

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Authors

SGShom GoelThe University of Melbourne DDDan G. DudaCornell University LXLei XuTongji University

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Implication

Scientific review reveals vascular normalization improves therapeutic delivery in solid tumors, suggesting a mechanism for the synergistic benefits of antiangiogenic combination therapies.

Key Points

To examine the pathophysiology of tumor angiogenesis, the molecular mechanisms driving vascular normalization, and the therapeutic implications of restoring vascular integrity in cancer and nonmalignant diseases.
Synthesized findings from preclinical tumor models and clinical trials evaluating anti-VEGF therapies as single agents and in combination with chemotherapy.
Reviewed genetic and pharmacological regulators of vessel maturation and oxygen sensing, including PHD2, PDGFRβ, RGS5, Ang1/2, and TGF-β.
Anti-VEGF monotherapy shows limited efficacy in regressing solid tumors, but combination with chemotherapy significantly improves overall survival across diverse cancer types.
Vascular normalization reduces vessel hyperpermeability, increases pericyte coverage, restores basement membranes, and lowers interstitial fluid pressure and hypoxia in preclinical models.
Restoration of tumor vasculature enhances the physical delivery of chemotherapeutic agents, potentiates radiotherapy and effector immune cell activity, and decreases circulating metastatic tumor cells.

Cite This Study

Goel et al. (2011) studied this question.

synapsesocial.com/papers/699562f810cb51f425ec4603 https://doi.org/10.1152/physrev.00038.2010

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Implication

Scientific review reveals vascular normalization improves therapeutic delivery in solid tumors, suggesting a mechanism for the synergistic benefits of antiangiogenic combination therapies.

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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