Key result
A combination of a renin inhibitor (Aliskiren) and Sambucus nigra polyphenolic extract significantly reduced systolic blood pressure (P<0.001) in rats with drug-induced hypertension.
Why the study?
Does the combination of Aliskiren and Sambucus nigra polyphenolic extract reduce blood pressure and oxidative stress in a rat model of hypertension?
Does the combination of Aliskiren and Sambucus nigra polyphenolic extract reduce blood pressure and oxidative stress in a rat model of hypertension?
p-value: p=<0.001
The combination of Aliskiren and Sambucus nigra extract synergistically improves antioxidant capacity and reduces blood pressure in hypertensive rats.
Should not change hypertension practice; leaves open translation of synergistic effects to human trials.
CONTEXT: The health effects of Sambucus nigra L. (Caprifoliaceae) could be due to polyphenols whose modes of action differ from the traditional one proposed for exogenous antioxidants. OBJECTIVE: The study emphasizes the effects of the association between the renin inhibitor and the polyphenolic extract on biochemical parameters and systolic (TAS) and diastolic (TAD) blood pressure within an L NAME-induced experimental model of arterial hypertension (AHT). MATERIALS AND METHODS: . The Wistar white rat blood pressure values were recorded using a CODA™ system, which uses a non-invasive blood pressure measuring method. RESULTS AND DISCUSSION: The total antioxidant capacity levels were significantly decreased (p < 0.001) in AHT group as compared to the rats in the AHT + PS group. A combination of a renin inhibitor (Aliskiren) and polyphenolic extract generated a superior antioxidant effect compared to administering the two separately. Both TAS and TAD in rats with drug-induced hypertension were reduced by polyphenolic extract. The homogeneous values of TAS record a significant decrease (p < 0.001) of the average values in AHT + PS group or AHT + Aliskiren group. CONCLUSION: The combination of two different classes of substances, namely, renin inhibitors and natural polyphenol extracts, reduces arterial pressure and also might reduce the side effects of the major classes of antihypertensive agents and improve the quality of live.
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Ciocoiu et al. (2016) studied L NAME-induced experimental model of arterial hypertension. Sambucus nigra polyphenolic extract and renin inhibitor (Aliskiren) vs. AHT group (control) or separate administration was evaluated on Total antioxidant capacity and systolic/diastolic blood pressure (p=<0.001). A combination of a renin inhibitor (Aliskiren) and Sambucus nigra polyphenolic extract significantly reduced systolic blood pressure (P<0.001) in rats with drug-induced hypertension.
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