Key result
Acute administration of 10 μM Aliskiren significantly decreased lipid peroxidation (TBARS), nitrite (NO2-), and hydrogen peroxide (H2O2) levels in isolated rat hearts at higher perfusion pressures.
Why the study?
Does Aliskiren reduce oxidative stress biomarkers in isolated rat hearts?
Does Aliskiren reduce oxidative stress biomarkers in isolated rat hearts?
Acute administration of the direct renin inhibitor Aliskiren at high doses reduces oxidative stress biomarkers in isolated rat hearts subjected to high perfusion pressures.
Answers are grounded in this paper and cite their sources.
Should not yet change practice; hypothesis-generating for aliskiren's antioxidant effects in human hearts.
Increased activity of the renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development and progression of various cardio-metabolic diseases, such as hypertension, atherosclerosis and heart failure. Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use. This study investigated the acute and direct effects of Aliskiren on different parameters of oxidative stress on isolated rat heart. The hearts of male Wistar albino rats (n = 24, 8 per experimental group, age 8 weeks, body mass 180–200 g), were excised and retrogradely perfused according to the Langendorfftechnique at a gradually increasing perfusion pressure (40-120 cmH 2 O). Markers of oxidative stress (NO 2 − , TBARS, H 2 O 2 and O 2 − ) were measured spectrophotometrically after perfusion with three different concentrations of Aliskiren (0.1 μM, 1 μM, and 10 μM). The results demonstrated possible dose-dependent cardioprotective properties of Aliskiren, particularly with higher CPP. Lipid peroxidation (TBARS) levels decreased with the highest dose of Aliskiren and higher CPP, and the same trend was observed in nitrite (NO 2 − ) and hydrogen peroxide (H 2 O 2 ) levels. These findings indicate that the acute effects of Aliskiren do not likely promote the production of reactive oxygen species upon higher pressure with the highest dose. Aliskiren may exert beneficial effects on oxidative stress biomarkers.
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Plećević et al. (2015) studied Oxidative stress (n=24). Aliskiren vs. Baseline/Control (each heart was its own control) was evaluated on Oxidative stress biomarkers (NO2-, TBARS, H2O2, O2-) (p=<0.05). Acute administration of 10 μM Aliskiren significantly decreased lipid peroxidation (TBARS), nitrite (NO2-), and hydrogen peroxide (H2O2) levels in isolated rat hearts at higher perfusion pressures.
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