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April 7, 2019Immunopathologia PersaOpen Access

Treatment with aliskiren and aliskiren plus L-arginine caused a significant decrease in serum levels of creatinine, urea, albumin/creatinine, and MDA, and an increase in GPX and SOD compared to the IR control group.

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Why the study?

The role of chemical drugs such as aliskiren has been evaluated in various kidney diseases, motivating an assessment of its effect on renal ischemia reperfusion.

Does aliskiren improve biochemical and oxidative stress parameters in a rat model of renal ischemia-reperfusion?

Population

Fifty male Wistar rats (220±10 g)

Comparison

Aliskiren alone, aliskiren plus L-NAME, aliskiren plus L-arginine, IR control, and healthy control

Design

Randomized animal study

Authors

LMLeila MohmoodniaSKSahar KoushkiMMMichele Moruzzi

Discussion

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Overview

Suggests a potential renoprotective role for direct renin inhibition in ischemia-reperfusion injury; leaves.

Structured PICO

Does aliskiren improve biochemical and oxidative stress parameters in a rat model of renal ischemia-reperfusion?

P
Population
50 male Wistar rats (220±10 g) subjected to renal ischemia-reperfusion (45 minutes of clamping)
I
Intervention
Aliskiren 30 mg/kg orally, alone or with L-NAME (40 mg/kg) or L-arginine (40 mg/kg)
C
Comparator
Ischemia of reperfusion (IR) control group and healthy control group
O
Outcome
Serum levels of creatinine, urea, albumin/creatinine, malondialdehyde (MDA), glutathione peroxidase (GPX), and superoxide dismutase (SOD)surrogate

Aliskiren demonstrates protective effects against renal ischemia-reperfusion injury in a rat model by improving renal function and reducing oxidative stress.

Cite This Study

Mohmoodnia et al. (2019) studied this question.

synapsesocial.com/papers/6a8d1795bc360c399acdb74ahttps://doi.org/10.15171/ipp.2019.10
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renoprotective effect of aliskiren on renal ischemia/reperfusion injury in rats: electron microscopy and molecular study2014 · 28 citations
  2. 2Does Aliskiren Protect the Kidney Following Ischemia Reperfusion Injury?2013 · 24 citations
  3. 3Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart2015
  4. 4Direct Renin Inhibition With Aliskiren Protects Against Myocardial Ischemia/Reperfusion Injury by Activating Nitric Oxide Synthase Signaling in Spontaneously Hypertensive Rats2014 · 37 citations
  5. 5Aliskiren protects against myocardial ischaemia‐reperfusion injury via an endothelial nitric oxide synthase dependent manner2016 · 15 citations