Aliskiren at 50 and 100 mg/kg significantly alleviated the increase of caspase-3 and cardiac marker enzymes and changes in antioxidant enzymes induced by isoproterenol.

Wistar albino rats (n=36)

Aliskiren (30, 50, or 100 mg/kg orally for 14 days) with isoproterenol (85 mg/kg subcutaneously on days 13 and 14)

Isoproterenol alone (85 mg/kg subcutaneously on days 13 and 14) and normal control (saline)

Cardiac marker enzymes (CK-MB, LDH), apoptotic marker (caspase-3), antioxidative enzymes (MDA, GSH, SOD, catalase), and histopathological analysis at 24 hours after the 14-day treatmentsurrogate