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November 3, 2016Clinical and Experimental Pharmacology and Physiology

Aliskiren improved LVEF and FS, decreased infarct size, and reduced oxidative stress in WT mice subjected to I/R injury, but failed to restore these indices in eNOS-/- mice.

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Why the study?

Does aliskiren protect against myocardial ischaemia-reperfusion injury in an eNOS-dependent manner in mice?

Population

12-week-old male eNOS knockout (eNOS-/-) and wild-type C57BL/6J mice (WT)

Comparison

Aliskiren 50 mg/kg per day orally for 4 weeks vs Untreated/vehicle mice subjected to the same…

Design

Preclinical

Follow-up

4 weeks of treatment, followed by 24 hours of reperfusion

Authors

YCYu ChenGMGuoliang MengWBWenli Bai

Discussion

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Overview

Aliskiren may confer eNOS-dependent protection in murine I/R injury; leaves open clinical translation.

Structured PICO

Does aliskiren protect against myocardial ischaemia-reperfusion injury in an eNOS-dependent manner in mice?

P
Population
12-week-old male eNOS knockout (eNOS-/-) and wild-type C57BL/6J mice (WT)
I
Intervention
Aliskiren 50 mg/kg per day orally for 4 weeks
C
Comparator
Untreated/vehicle mice subjected to the same ischaemia-reperfusion injury (implied)
O
Outcome
Myocardial ischaemia-reperfusion injury indices (LVEF, FS, infarct size, CK, LDH, oxidative stress markers) after 30 minutes of ischaemia followed by 24 hours of reperfusionsurrogate

Aliskiren protects against myocardial ischaemia-reperfusion injury through an eNOS-dependent mechanism in a mouse model.

Cite This Study

Chen et al. (2016) studied this question.

synapsesocial.com/papers/6a8bbb79f19228bbb2fb5cb3https://doi.org/10.1111/1440-1681.12692
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct Renin Inhibition With Aliskiren Protects Against Myocardial Ischemia/Reperfusion Injury by Activating Nitric Oxide Synthase Signaling in Spontaneously Hypertensive Rats2014 · 37 citations
  2. 2Renin Inhibition Improves Cardiac Function and Remodeling After Myocardial Infarction Independent of Blood Pressure2008 · 94 citations
  3. 3Aliskiren Enhances the Protective Effects of Valsartan Against Cardiovascular and Renal Injury in Endothelial Nitric Oxide Synthase–Deficient Mice2009 · 66 citations
  4. 4Renoprotective effect of aliskiren on renal ischemia/reperfusion injury in rats: electron microscopy and molecular study2014 · 28 citations
  5. 5Renin Inhibition by Aliskiren Protects Rats Against Isoproterenol Induced Myocardial Infarction2017 · 11 citations