What is the clinical evidence from this study?

Study design: Other. Population: Cardiovascular and renal injury in endothelial NO synthase-deficient mice. Intervention: Combined aliskiren and valsartan vs. Vehicle, aliskiren alone, valsartan alone, and hydralazine. Primary outcome: Cardiovascular and renal injury (cardiac hypertrophy, inflammation, fibrosis, coronary remodeling, arterial intimal thickening, urinary albumin excretion, glomerular inflammation, and glomerulosclerosis).

What does this research mean for the field?

The combination of aliskiren and valsartan synergistically attenuates cardiovascular and renal injury and tissue oxidative stress in endothelial nitric oxide synthase-deficient mice compared with monotherapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 14, 2009Hypertension

Aliskiren Enhances the Protective Effects of Valsartan Against Cardiovascular and Renal Injury in Endothelial Nitric Oxide Synthase–Deficient Mice

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Key result

Combined aliskiren and valsartan synergistically attenuates CV and renal injury in mice vs monotherapy.

Why the study?

Does the combination of aliskiren and valsartan improve cardiovascular and renal injury in endothelial NO synthase-deficient mice?

Population

Endothelial NO synthase-deficient mice subjected to cuff injury of femoral artery

Comparison

Combined aliskiren and valsartan for 4 weeks vs Vehicle; aliskiren alone; valsartan alone…

Design

Preclinical

Follow-up

4 weeks

Authors

EYEiichiro Yamamoto KKKeiichiro Kataoka YDYi‐Fei Dong

Discussion

Member takes

Overview

Hypothesis-generating for dual renin-angiotensin blockade in endothelial dysfunction; does not support clinical use.

Structured PICO

Does the combination of aliskiren and valsartan improve cardiovascular and renal injury in endothelial NO synthase-deficient mice?

Population

Endothelial NO synthase-deficient mice subjected to cuff injury of femoral artery, treated for 4 weeks.

Intervention

Combined aliskiren (12.5 mg/kg per day) and valsartan (4 mg/kg per day) for 4 weeks

Comparator

Vehicle; aliskiren alone (25 mg/kg per day); valsartan alone (8 mg/kg per day); hydralazine (10 mg/kg per day)

Outcome

Cardiovascular and renal injury (cardiac hypertrophy, inflammation and fibrosis, coronary remodeling, arterial intimal thickening, urinary albumin excretion, glomerular inflammation, and glomerulosclerosis)surrogate

The combination of aliskiren and valsartan exerts synergistic protective effects against cardiovascular and renal injury through attenuation of oxidative stress in a mouse model.

Cite This Study

Yamamoto et al. (2009) studied Cardiovascular and renal injury in endothelial NO synthase-deficient mice. Combined aliskiren and valsartan vs. Vehicle, aliskiren alone, valsartan alone, and hydralazine was evaluated on Cardiovascular and renal injury (cardiac hypertrophy, inflammation, fibrosis, coronary remodeling, arterial intimal thickening, urinary albumin excretion, glomerular inflammation, and glomerulosclerosis). The combination of aliskiren and valsartan synergistically attenuated cardiovascular and renal injuries and oxidative stress in endothelial NO synthase-deficient mice compared to monotherapy.

synapsesocial.com/papers/6aa5c0b950dab972bddd57ae https://doi.org/10.1161/hypertensionaha.109.133884

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July 14, 2009Hypertension

Aliskiren Enhances the Protective Effects of Valsartan Against Cardiovascular and Renal Injury in Endothelial Nitric Oxide Synthase–Deficient Mice

View Full Paper

Ask AI

Bookmark

Key result

Combined aliskiren and valsartan synergistically attenuates CV and renal injury in mice vs monotherapy.

Why the study?

Does the combination of aliskiren and valsartan improve cardiovascular and renal injury in endothelial NO synthase-deficient mice?

Population

Endothelial NO synthase-deficient mice subjected to cuff injury of femoral artery

Comparison

Combined aliskiren and valsartan for 4 weeks vs Vehicle; aliskiren alone; valsartan alone…

Design

Preclinical

Follow-up

4 weeks

Authors

EYEiichiro Yamamoto KKKeiichiro Kataoka YDYi‐Fei Dong

Discussion

Member takes

Overview

Hypothesis-generating for dual renin-angiotensin blockade in endothelial dysfunction; does not support clinical use.

Structured PICO

Does the combination of aliskiren and valsartan improve cardiovascular and renal injury in endothelial NO synthase-deficient mice?

Population

Endothelial NO synthase-deficient mice subjected to cuff injury of femoral artery, treated for 4 weeks.

Intervention

Combined aliskiren (12.5 mg/kg per day) and valsartan (4 mg/kg per day) for 4 weeks

Comparator

Vehicle; aliskiren alone (25 mg/kg per day); valsartan alone (8 mg/kg per day); hydralazine (10 mg/kg per day)

Outcome

The combination of aliskiren and valsartan exerts synergistic protective effects against cardiovascular and renal injury through attenuation of oxidative stress in a mouse model.

Cite This Study

synapsesocial.com/papers/6aa5c0b950dab972bddd57ae https://doi.org/10.1161/hypertensionaha.109.133884

Also Consider

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