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July 22, 2008Hypertension

Renin Inhibitor Aliskiren Improves Impaired Nitric Oxide Bioavailability and Protects Against Atherosclerotic Changes

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Why the study?

Does aliskiren alone or in combination with valsartan improve NO bioavailability and protect against atherosclerotic changes in Watanabe heritable hyperlipidemic rabbits?

Population

Watanabe heritable hyperlipidemic rabbits

Comparison

Aliskiren, valsartan, or aliskiren plus… vs Vehicle (control)

Design

Preclinical

Follow-up

8 weeks

Authors

TIToshio ImanishiHTHiroto TsujiokaHIHideyuki Ikejima

Discussion

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Overview

Adds preclinical support for dual aliskiren-valsartan endothelial effects in rabbits; leaves open translation to human atherosclerosis.

Structured PICO

Does aliskiren alone or in combination with valsartan improve NO bioavailability and protect against atherosclerotic changes in Watanabe heritable hyperlipidemic rabbits?

P
Population
Watanabe heritable hyperlipidemic rabbits
I
Intervention
Aliskiren, valsartan, or aliskiren plus valsartan for 8 weeks
C
Comparator
Vehicle (control)
O
Outcome
Acetylcholine-induced NO productionsurrogate

Cotreatment with a direct renin inhibitor and an angiotensin II receptor blocker has additive protective effects on endothelial function and atherosclerotic changes in a hyperlipidemic rabbit model.

Cite This Study

Imanishi et al. (2008) studied this question.

synapsesocial.com/papers/6a72b620f44fa9f079e01746https://doi.org/10.1161/hypertensionaha.108.111120
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pharmacologic Demonstration of the Synergistic Effects of a Combination of the Renin Inhibitor Aliskiren and the AT1 Receptor Antagonist Valsartan on the Angiotensin II–Renin Feedback Interruption2004 · 235 citations
  2. 2Blood Pressure Lowering in Essential Hypertension With an Oral Renin Inhibitor, Aliskiren2003 · 342 citations
  3. 3Effects of Angiotensin II on NO Bioavailability Evaluated Using a Catheter-Type NO Sensor2006 · 40 citations
  4. 4Aliskiren, a Novel Orally Effective Renin Inhibitor, Provides Dose-Dependent Antihypertensive Efficacy and Placebo-Like Tolerability in Hypertensive Patients2005 · 525 citations
  5. 5Pathways for Angiotensin II Generation in Intact Human Tissue1998 · 340 citations