Why the study?
Does aliskiren alone or in combination with atorvastatin reduce atherosclerosis development and improve plaque stability in APOE*3Leiden.CETP transgenic mice?
Does aliskiren alone or in combination with atorvastatin reduce atherosclerosis development and improve plaque stability in APOE*3Leiden.CETP transgenic mice?
Aliskiren inhibits atherosclerosis development and improves plaque stability in a transgenic mouse model, with potential additive benefits when combined with atorvastatin.
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Should not change practice; hypothesis-generating for aliskiren in atherosclerosis models, pending human trials.
Kühnast et al. (2011) studied this question.
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