Why the study?
Does dual renin-angiotensin system inhibition with valsartan and aliskiren improve hemodynamics and hormonal profiles without causing renal damage in hypertensive rats?
Population
39 congenic mRen2.Lewis hypertensive rats
Comparison
Valsartan, aliskiren, or combination of both for… vs Vehicle (n=9)
Design
Preclinical
Follow-up
2 weeks
Authors
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May caution against dual RAS blockade due to renal worsening in rats; leaves open clinical safety of combination therapy.
Does dual renin-angiotensin system inhibition with valsartan and aliskiren improve hemodynamics and hormonal profiles without causing renal damage in hypertensive rats?
Dual RAS blockade with valsartan and aliskiren improves blood pressure and proteinuria in hypertensive rats but causes paradoxical worsening of renal parenchymal disease.
Moniwa et al. (2012) studied this question.
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