Why the study?
Does aliskiren alone or combined with valsartan improve diabetic nephropathy in db/db mice?
Population
db/db mice (model of type 2 diabetic nephropathy)
Comparison
Aliskiren, valsartan, combined aliskiren and… vs Compared among each treatment group
Design
Preclinical
Follow-up
6 weeks
Authors
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Supports additive renoprotection in diabetic mouse models; leaves open clinical translation and human trials.
Does aliskiren alone or combined with valsartan improve diabetic nephropathy in db/db mice?
Aliskiren provides protective effects against type 2 diabetic nephropathy and enhances the protective effects of valsartan in a mouse model.
Dong et al. (2010) studied this question.
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