Key result
Neuropilin-1 overexpression ameliorated cerebral ischemia/reperfusion-induced damage to motor function and restored mitochondrial morphology in rats by activating the Wnt/β-catenin signaling pathway.
Why the study?
Whether neuropilin-1 (NRP-1) can repair mitochondrial structure and promote functional recovery after cerebral ischemia was unknown.
Does NRP-1 overexpression improve mitochondrial structural repair and functional recovery in a rat model of cerebral ischemia?
Population
Adult male SD rats subjected to tMCAO and rat primary cortical neuronal cultures subjected to OGD/R
Comparison
AAV-NRP-1 or LV-NRP-1 administration vs controls with or without XAV-939
Design
In vivo and in vitro animal experimental study
Authors
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NRP-1 overexpression merits further preclinical testing in cerebral I/R; leaves open translation to human stroke therapy.
Does NRP-1 overexpression improve mitochondrial structural repair and functional recovery in a rat model of cerebral ischemia?
NRP-1 overexpression protects against cerebral ischemia/reperfusion injury by activating the Wnt/β-catenin signaling pathway to promote mitochondrial repair and functional recovery in a rat model.
Guo et al. (2023) studied Cerebral ischemia. Neuropilin-1 (NRP-1) overexpression vs. Sham or empty vector was evaluated on Motor function and mitochondrial morphology. Neuropilin-1 overexpression ameliorated cerebral ischemia/reperfusion-induced damage to motor function and restored mitochondrial morphology in rats by activating the Wnt/β-catenin signaling pathway.
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