Key result
Recovery from COVID-19 was associated with significantly decreased time and frequency domain heart rate variability parameters compared to healthy controls, indicating autonomic dysfunction.
Why the study?
Autonomic dysfunction may occur during acute COVID-19, prompting evaluation of cardiac autonomic function using heart rate variability in outpatient subjects recovered from symptomatic COVID-19.
Does recovery from symptomatic COVID-19 alter cardiac autonomic function as measured by heart rate variability compared to healthy controls?
Case-Control (n=100)
Does recovery from symptomatic COVID-19 alter cardiac autonomic function as measured by heart rate variability compared to healthy controls?
Patients who have recovered from symptomatic COVID-19 exhibit significant alterations in heart rate variability, suggesting the presence of preclinical cardiac autonomic dysfunction.
May indicate subclinical autonomic dysfunction post-COVID; hypothesis-generating and requires prospective validation before clinical implications.
Background Autonomic dysfunction may occur during the acute phase of COVID‐19. Heart rate variability (HRV) is a useful tool for the assessment of cardiac sympathetic and parasympathetic balance. We aimed to evaluate cardiac autonomic function by using HRV in subjects after recovery from COVID‐19 who had previously symptomatic and were followed outpatiently. Methods The study group composed of 50 subjects with a confirmed history of COVID‐19 and the control group composed of 50 healthy subjects without a history of COVID‐19 and vaccination. All the study participants underwent 2‐dimensional, pulsed‐ and tissue‐Doppler echocardiographic examinations and 24‐hour Holter monitoring for HRV analysis. Results Time domain parameters of SDNN, SDANN, SDNNi, RMSSD, pNN50, and HRV triangular index were all decreased in the study group when compared with the control group. Frequency domain parameters of TP, VLF, LF, HF, and HFnu were also decreased in the study group in comparison with the control group. LFnu was similar between groups. Nonlinear parameters of HRV including α1and α2decreased in the study group. By contrast, Lmax, Lmean, DET, REC, and Shannon entropy increased in the study population. Approximate and sample entropies also enhanced in the study group. Conclusions The present study showed that all three domain HRV significantly altered in patients after recovery from COVID‐19 indicating some degree of dysfunction in cardiac autonomic nervous system. HRV may be a useful tool for the detection of preclinical autonomic dysfunction in this group of patients.
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Kurtoğlu et al. (2021) conducted a case-control in COVID-19 recovery (n=100). Recovery from COVID-19 vs. Healthy subjects without a history of COVID-19 and vaccination was evaluated on Heart rate variability (HRV) parameters. Recovery from COVID-19 was associated with significantly decreased time and frequency domain heart rate variability parameters compared to healthy controls, indicating autonomic dysfunction.
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