Studies on gastric proteolysis. 2. The nature of the enzyme–substrate interaction responsible for gastric proteolytic pH–activity curves with two maxima

Human gastric juice and swine and calf gastricmucosal extracts have been shown to digest proteins other than egg albumin with two and occasionally three pH maxima below pH 5, under experimental conditions which exclude the possibility that the maxima result from the presence of buffer anions or of more than one substrate com- ponent (Taylor, 1956, 1959).