Key result
Colchicine use in patients with renal insufficiency can cause a severe myoneuropathy characterized by prominent clinical and electrophysiologic myotonia that resolves completely upon discontinuation.
Why the study?
Does discontinuation of colchicine resolve myoneuropathy and myotonia in patients with renal insufficiency?
Case Report (n=4)
Does discontinuation of colchicine resolve myoneuropathy and myotonia in patients with renal insufficiency?
Colchicine myoneuropathy can present with prominent myotonia in patients with renal insufficiency, which resolves completely upon discontinuation of the drug.
No takes yet. Share an insight, caveat, or question.
Colchicine discontinuation may resolve myoneuropathy with myotonia in renal insufficiency; hypothesis-generating case report requiring prospective validation.
Rutkove et al. (1996) conducted a case report in Colchicine myoneuropathy (n=4). Colchicine was evaluated on Development of myoneuropathy with myotonic discharges and resolution upon discontinuation. Colchicine use in patients with renal insufficiency can cause a severe myoneuropathy characterized by prominent clinical and electrophysiologic myotonia that resolves completely upon discontinuation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: