Key result
Younger age (18-54 years) was associated with a higher adjusted risk of 30-day all-cause unplanned readmission after AMI and PCI compared to ages 55-64 (AOR 1.06; 95% CI 1.01-1.11; p=0.0129).
Why the study?
Does age affect the risk of 30-day unplanned readmission in adult patients with AMI undergoing PCI?
Cohort (n=492,550)
Yes
Does age affect the risk of 30-day unplanned readmission in adult patients with AMI undergoing PCI?
Odds Ratio: 1.06 (95% CI 1.01–1.11)
p-value: p=0.0129
Younger patients (18-54 years) with AMI undergoing PCI have a paradoxically higher adjusted risk of 30-day unplanned readmission compared to middle-aged patients, highlighting the need for age-targeted transitional care initiatives.
Supports enhanced transitional care for younger post-AMI/PCI patients; leaves open causality and intervention effects.
Objective This study aimed to investigate the association between age and the risk of 30-day unplanned readmission among adult patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Methods This retrospective analysis included patients from the Nationwide Readmissions Database with AMI who underwent PCI during 2013–2014. We used multivariable logistic regression model to calculate adjusted odds ratios (AORs) for risk of readmission. To examine potential non-linear association, we performed logistic regression with restricted cubic splines (RCS). Results Of the 492 550 patients with AMI aged above 18 years undergoing PCI during the index hospitalisation, 48 630 (9.87%) were readmitted within 30 days. Although the crude readmission rate of younger patients (aged 18–54 years) was the lowest (7.27%), younger patients had higher risk of readmission compared with patients aged 55–64 years for all-causes (AOR 1.06 (1.01 to 1.11), p=0.0129) and specific causes, such as AMI and chest pain (both cardiac and non-specific) after adjusted for covariates. Patients aged 65–74 years were at lower risk of all-cause readmission. Older patients (age ≥75 years) had higher risk of readmission for heart failure (AOR 1.50 (1.29 to 1.74)) and infection (AOR 1.44 (1.16 to 1.79)), but lower risk for chest pain. RCS analyses showed a U-shaped relationship between age and readmission risk. Conclusions Our results suggest higher risk of readmission in younger patients for all-cause unplanned readmission after adjusted for covariates. The trends of readmission risk along with age were different for specific causes. Age-targeted initiatives are warranted to reduce preventable readmissions in patients with AMI undergoing PCI.
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Jonathan R. Skinner (1998) conducted a cohort in Acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) (n=492,550). Younger age (18-54 years) vs. Age 55-64 years was evaluated on 30-day all-cause unplanned readmission (AOR 1.06, 95% CI 1.01 to 1.11, p=0.0129). Younger age (18-54 years) was associated with a higher adjusted risk of 30-day all-cause unplanned readmission after AMI and PCI compared to ages 55-64 (AOR 1.06; 95% CI 1.01-1.11; p=0.0129).
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