Key result
Pre-irradiation treatment of Tradescantia microspores with protein synthesis inhibitors or amino acids reduced X-ray-induced chromosomal aberration yields from 0.24 to as low as 0.14 per cell.
Inhibitors of protein synthesis and certain amino acids enhance recovery from radiation damage in Tradescantia microspores, likely by increasing available ATP for chromosome rejoining.
No immediate clinical implications for radiotherapy; hypothesis-generating for protein synthesis in radiation recovery across models.
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Beatty et al. (1963) studied Radiation-induced chromosomal damage. Protein synthesis inhibitors (dihydrostreptomycin, puromycin, chloramphenicol) and amino acids vs. Helium control (untreated) was evaluated on Chromosomal aberration yield (average interchanges per cell). Pre-irradiation treatment of Tradescantia microspores with protein synthesis inhibitors or amino acids reduced X-ray-induced chromosomal aberration yields from 0.24 to as low as 0.14 per cell.
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