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January 1, 1963Proceedings of the National Academy of SciencesOpen Access

Depression of Host-Controlled Rna Synthesis in Human Cells During Poliovirus Infection

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Population

Human cells

Design

Preclinical

Authors

JHJohn J. HollandKing's College London

Discussion

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Implication

Hypothesis-generating for poliovirus host shutoff mechanisms; leaves open relevance to human pathogenesis pending in vivo studies.

Structured PICO

P
Population
Human cells
I
Intervention
Poliovirus infection
O
Outcome
Depression of host-controlled RNA synthesis

Poliovirus infection depresses host-controlled RNA synthesis in human cells.

Cite This Study

John J. Holland (1963) studied this question.

synapsesocial.com/papers/6a8a77a11e528df4f2ec73cehttps://doi.org/10.1073/pnas.49.1.23
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  3. 3ALTERED BASE RATIOS IN RNA SYNTHESIZED DURING ENTEROVIRUS INFECTION OF HUMAN CELLS1962 · 16 citations
  4. 4THE EFFECT OF MENGOVIRUS INFECTION ON THE ACTIVITY OF THE DNA-DEPENDENT RNA POLYMERASE OF L-CELLS1962 · 111 citations