Key result
Under certain in vitro conditions of double infection, the protein capsid of a replicating type 2 poliovirus or Coxsackie B1 virus enclosed the RNA of type 1 poliovirus to form mature hybrid virus particles.
Demonstrates that the RNA genome of one enterovirus can be encapsidated by the protein capsid of a heterologous enterovirus during simultaneous infection.
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Holland et al. (1964) studied Poliovirus infection (in vitro). Heterologous enterovirus superinfection (type 2 poliovirus or Coxsackie B1 virus) vs. Guanidine-dependent type 1 poliovirus alone was evaluated on Production of mature guanidine-dependent type 1 poliovirus in the absence of guanidine. Under certain in vitro conditions of double infection, the protein capsid of a replicating type 2 poliovirus or Coxsackie B1 virus enclosed the RNA of type 1 poliovirus to form mature hybrid virus particles.
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