Palladium‐Catalyzed CF Bond Formation via Directed CH Activation

Palladium‐catalyzed CF bond formation via directed CH activation has recently emerged as a significant method to introduce fluorine atoms into organic molecules in an atom‐ and step‐economical path. At the interface between fluorine chemistry and synthetic organic chemistry, the development of direct fluorinations of the CH bond remains sluggish, due to the major challenge of reductive elimination to afford the CF bond. One strategy is to oxidize palladium(II) species to more electron‐deficient palladium(IV or III) fluorides to promote the CF bond forming reductive elimination, which opens up palladium‐catalyzed CH fluorination as a powerful transformation. This focused review gives a brief summary of the mere handful of examples, including C(sp2)F and C(sp3)F bond formations, in this field so far. magnified image