BACKGROUND: 9-cis-Retinoic acid (9-cis-RA) has a particular pattern of binding and activating retinoid receptors. Treatment of chronic hand eczema is often refractory to conventional treatment. OBJECTIVE: Evaluation of oral 9-cis-RA therapy in chronic hand eczema in a pilot study. METHODS: Thirty-eight patients with refractory chronic hand eczema were treated in an exploratory open-label study with oral 9-cis-RA. RESULTS: Twenty-one (55%) showed a very good response, 13 (34%) a good response, 2 (5.5%) a moderate response and 2 (5.5%) no response. Side effects were mild. CONCLUSION: 9-cis-RA is a valuable drug when given at low doses to patients with chronic hand eczema.
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Bollag et al. (1999) studied this question.