Key result
In patients with lung metastatic osteosarcoma, median post-lung metastases overall survival was 16 months for those with synchronous metastases compared to 9 months for those with metachronous metastases.
Why the study?
What are the clinicopathological characteristics and outcomes of osteosarcoma patients with synchronous versus metachronous lung metastases?
Population
93 adolescent and adult patients with high-grade osteosarcoma and lung metastases, median age 19 years…
Comparison
Synchronous lung metastases (Group A, n=39) vs Metachronous lung metastases (Group B, n=54)
Design
Cohort
Follow-up
Median 115 months and median 91 months
Authors
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Synchronous lung metastases linked to longer survival than metachronous in osteosarcoma; hypothesis-generating and should not yet change practice.
Cohort (n=93)
No
What are the clinicopathological characteristics and outcomes of osteosarcoma patients with synchronous versus metachronous lung metastases?
Absolute Event Rate: 16% vs 9%
p-value: p=<0.001
In patients with lung metastatic osteosarcoma, time to lung metastases, number of nodules, pulmonary metastasectomy, and chemotherapy are independent prognostic factors for post-lung metastases survival.
Durnalı et al. (2016) conducted a cohort in Lung metastatic osteosarcoma (n=93). Synchronous lung metastases vs. Metachronous lung metastases was evaluated on Median post-lung metastases overall survival (PLM-OS) in months (p=<0.001). In patients with lung metastatic osteosarcoma, median post-lung metastases overall survival was 16 months for those with synchronous metastases compared to 9 months for those with metachronous metastases.
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