Key result
The rs2200733 TT genotype on chromosome 4q25 was significantly associated with an increased risk of atrial fibrillation recurrence compared to the CC genotype (OR 1.336).
Why the study?
Studies showed controversial results regarding the effect of common genetic polymorphisms on atrial fibrillation recurrence.
Are common genetic polymorphisms associated with the risk of atrial fibrillation recurrence?
Meta-Analysis (n=3,204)
Are common genetic polymorphisms associated with the risk of atrial fibrillation recurrence?
Odds Ratio: 1.336 (95% CI 1.061–1.683)
p-value: p=0.014
Genetic variants rs2200733 and rs10033464 on chromosome 4q25 are significantly associated with an increased risk of atrial fibrillation recurrence.
Supports rs2200733 genotyping for post-ablation AF risk stratification; confirms the association via meta-analysis of observational data.
BACKGROUND: Studies showed the controversial results about the effect of common genetic polymorphisms on the atrial fibrillation (AF) recurrence. We performed the systematic review and meta-analysis to qualify the association between common genetic polymorphisms and AF recurrence. METHODS: Articles were systematically retrieved PubMed, Web of Science, EMBASE, Wanfang, and CNKI database and 9 studies including 3204 patients were enrolled in our meta-analysis. RESULTS: Results showed that the associations were significant under rs2200733 3 genetic models (TT vs CC: odds ratio [OR] [confidence interval [CI]] = 1.336 [1.061-1.683], P = .014; CT vs CC: OR [CI] = 0.759 [0.614-0.937], P = .01; TT vs CT + CC: OR [CI] = 2.308 [1.440-3.700], P = .001). The association was significant under rs10033464 genetic model (TT vs GG: OR [CI] = 1.517 [1.165-1.976], P = .002). CONCLUSIONS: Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis. In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence.
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Jiang et al. (2019) conducted a meta-analysis in Atrial fibrillation (n=3,204). rs2200733 variant on chromosome 4q25 (TT genotype) vs. CC genotype was evaluated on Atrial fibrillation recurrence (OR 1.336, 95% CI 1.061-1.683, p=0.014). The rs2200733 TT genotype on chromosome 4q25 was significantly associated with an increased risk of atrial fibrillation recurrence compared to the CC genotype (OR 1.336).
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