Key result
The ZFHX3 genetic variant rs12373097 was significantly associated with an increased risk of atrial fibrillation recurrence after catheter ablation (OR 1.57).
Why the study?
Do AF susceptibility genes (PITX2, KCNN3, ZFHX3) associate with left atrial enlargement, persistent AF, and AF recurrence after catheter ablation in patients with non-valvular AF?
Cohort (n=660)
No
Do AF susceptibility genes (PITX2, KCNN3, ZFHX3) associate with left atrial enlargement, persistent AF, and AF recurrence after catheter ablation in patients with non-valvular AF?
Odds Ratio: 1.57 (95% CI 1.18–2.08)
p-value: p=0.002
The ZFHX3 gene is associated with left atrial dilatation and an increased risk of atrial fibrillation recurrence following catheter ablation.
No takes yet. Share an insight, caveat, or question.
Associated with higher post-ablation AF recurrence risk; hypothesis-generating and should not yet change practice.
Husser et al. (2017) conducted a cohort in Non-valvular atrial fibrillation (n=660). ZFHX3 genetic variants (rs12373097) vs. Absence of variant was evaluated on Atrial fibrillation recurrence between 3 and 12 months after catheter ablation (OR 1.57, 95% CI 1.18-2.08, p=0.002). The ZFHX3 genetic variant rs12373097 was significantly associated with an increased risk of atrial fibrillation recurrence after catheter ablation (OR 1.57).
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