EtAlCl2‐promoted additions of organocopper reagents to camphor‐derived, conjugated N‐enoyl‐sultams gave saturated and olefinic β‐silylcarboxyl derivatives with high diastereodifferentiation. Nondestructive removal of the chiral auxiliary followed by oxidative Si‐C bond cleavage furnished enantiomerically pure acetate‐derived aldols and propionate‐derived ‘anti’ ‐aldols (via silyl‐directed α‐methylation).
No takes yet. Share an insight, caveat, or question.
Oppolzer et al. (1986) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: