Key result
A spontaneous primary undifferentiated pleomorphic sarcoma arising from the pancreas was identified in a 6-month-old female laboratory Wistar rat, representing the first reported case of its kind.
Case Report (n=1)
This represents the first reported case of a spontaneous primary undifferentiated pleomorphic sarcoma arising from the pancreas of a laboratory rat.
Spontaneous rat pancreatic UPS/MFH is hypothesis-generating; leaves open new spontaneous sarcoma models without clinical translation.
We present a case of spontaneous undifferentiated/unclassified sarcoma, of a pleomorphic subtype formerly known as malignant fibrous histiocytoma (UPS/MFH), arising from the pancreas of a laboratory rat. The mass was excised after laparotomy from a 6-month-old female laboratory Wistar rat. It presented a giant multilobulated mass of irregular shape, which had arisen from the pancreas and occupied almost the entire peritoneal cavity. Histologically the tumor was characterized by a highly variable morphological pattern, with frequent transitions from storiform to pleomorphic areas. An extensive immunohistochemical examination revealed no specific lines of differentiation. Immunohistochemical positivity was observed only to MIB-1 (high Ki-67 proliferation index), vimentin and CD68 antibodies. The diagnosis was compatible with UPS/MFH. To the best of our knowledge, the present case is the first report of a spontaneous primary UPS/MFH arising from the pancreas of a laboratory rat.
No takes yet. Share an insight, caveat, or question.
Ypsilantis et al. (2019) conducted a case report in Spontaneous pancreatic undifferentiated pleomorphic sarcoma (n=1). Spontaneous pancreatic undifferentiated pleomorphic sarcoma was evaluated on Histological and immunohistochemical diagnosis. A spontaneous primary undifferentiated pleomorphic sarcoma arising from the pancreas was identified in a 6-month-old female laboratory Wistar rat, representing the first reported case of its kind.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: