Key result
A 23-month-old Sprague-Dawley rat presented with an undifferentiated pleomorphic sarcoma characterized by the absence of multinucleated giant cells and significant mast cell infiltration.
Case Report (n=1)
This case report describes a rare presentation of undifferentiated pleomorphic sarcoma in a rat characterized by mast cell infiltration and absence of multinucleated giant cells, suggesting a potential role for mast cells in UPS pathology.
Undifferentiated pleomorphic sarcomas (UPSs) are tumours of mesenchymal origin typically seen in soft tissues and histologically characterized by pleomorphic tumour cell and multinucleated giant cell (MGC) infiltration. Here, we report UPS in a 23-month-old Sprague-Dawley rat, notable for the absence of MGC infiltration and the presence of mast cells. The tumour was located in the left axillary region and was assessed using haematoxylin and eosin, Masson's trichrome, and toluidine blue staining, along with immunohistochemistry. Neoplastic cells showed pleomorphism and storiform arrangement, with no MGCs, but with significant mast cell infiltration. Vimentin positivity confirmed the mesenchymal origin. The results in this case indicate a potential role of mast cells in UPS pathology and emphasize the need for further studies on their role in tumour progression.
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Sung et al. (2025) conducted a case report in Undifferentiated pleomorphic sarcoma (n=1). A 23-month-old Sprague-Dawley rat presented with an undifferentiated pleomorphic sarcoma characterized by the absence of multinucleated giant cells and significant mast cell infiltration.
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