What is the clinical evidence from this study?

Study design: Case Report. Population: G-CSF-producing Undifferentiated Pleomorphic Sarcoma (n=1). Intervention: Surgical resection and adjuvant chemotherapy. Primary outcome: Resolution of inflammatory reaction and recurrence-free survival.

What question did this study set out to answer?

To describe a rare case of primary granulocyte colony-stimulating factor-producing undifferentiated pleomorphic sarcoma located near the ascending colon and iliopsoas muscle.

June 26, 2019Internal MedicineOpen Access

G-CSF-producing Undifferentiated Pleomorphic Sarcoma Adjacent to the Ascending Colon and in the Right Iliopsoas Muscle: A Case Report and Review of the Literature

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Key result

Surgical resection of a rare G-CSF-producing undifferentiated pleomorphic sarcoma adjacent to the ascending colon led to immediate resolution of inflammatory reactions and one-year recurrence-free survival.

Population

One patient with primary UPS adjacent to the ascending colon and in the right iliopsoas muscle

Design

Case report and review of the literature

Follow-up

One year

Authors

SKShinsuke KazamaSaitama Cancer Center TGTabu GokitaSaitama Cancer Center MTMichitoshi TakanoJapan Community Healthcare Organization

Discussion

Member takes

Implication

May support resection for paraneoplastic symptoms in rare G-CSF sarcomas; leaves open generalizability from single case.

Key Points

To describe a rare case of primary granulocyte colony-stimulating factor-producing undifferentiated pleomorphic sarcoma located near the ascending colon and iliopsoas muscle.
Assessed a patient presenting with abdominal masses, fever, leukocytosis, and elevated C-reactive protein using abdominal computed tomography and 18F-FDG PET imaging.
Performed surgical resection of the tumor followed by adjuvant chemotherapy and monitored clinical status over a one-year follow-up.
Identified tumor-secreted granulocyte colony-stimulating factor as the driver of the patient's leukocytosis, high-grade fever, elevated C-reactive protein, and hematopoietic activation.
Surgical removal of the masses led to immediate cessation of the systemic inflammatory response, with the patient surviving one year post-resection without tumor recurrence.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 50-year-old man with G-CSF-producing undifferentiated pleomorphic sarcoma adjacent to the ascending colon and in the right iliopsoas muscle, treated with surgical resection and adjuvant chemotherapy, and followed for 1 year.

Intervention

Surgical resection (right hemi-colectomy with regional lymph node dissection, composite resection of the right transverse abdominal muscle, and resection of the right iliopsoas muscle) followed by 3 courses of adjuvant chemotherapy with doxorubicin (60 mg/m2).

Surgical resection of a rare G-CSF-producing undifferentiated pleomorphic sarcoma successfully resolved the associated severe inflammatory reaction and leukocytosis.

Cite This Study

Kazama et al. (2019) conducted a case report in G-CSF-producing Undifferentiated Pleomorphic Sarcoma (n=1). Surgical resection and adjuvant chemotherapy was evaluated on Resolution of inflammatory reaction and recurrence-free survival. Surgical resection of a rare G-CSF-producing undifferentiated pleomorphic sarcoma adjacent to the ascending colon led to immediate resolution of inflammatory reactions and one-year recurrence-free survival.

synapsesocial.com/papers/6a751f5df1e99ff85ab1da03 https://doi.org/10.2169/internalmedicine.2762-19

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G-CSF-producing Undifferentiated Pleomorphic Sarcoma Adjacent to the Ascending Colon and in the Right Iliopsoas Muscle: A Case Report and Review of the Literature

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

G-CSF-producing Undifferentiated Pleomorphic Sarcoma Adjacent to the Ascending Colon and in the Right Iliopsoas Muscle: A Case Report and Review of the Literature

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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