Key result
In a 71-year-old female with primary gastric undifferentiated pleomorphic sarcoma, R0 resection and adjuvant doxorubicin chemotherapy resulted in tumor recurrence two months postoperatively.
Why the study?
Primary undifferentiated pleomorphic sarcoma of the stomach is exceedingly rare with nonspecific presentation, making preoperative diagnosis challenging.
Case Report (n=1)
Primary gastric undifferentiated pleomorphic sarcoma is a highly aggressive tumor with a dismal prognosis and rapid recurrence despite multimodal therapy.
Answers are grounded in this paper and cite their sources.
Rare gastric UPS case underscores postoperative histopathology needs; extends sparse literature but leaves optimal management open.
Introduction: Undifferentiated pleomorphic sarcoma (UPS) is a rare and aggressive malignant soft tissue sarcoma. While most commonly arising in the extremities and trunk, primary occurrence in the stomach is exceedingly rare. Due to its rarity and nonspecific presentation, preoperative diagnosis is challenging and often established postoperatively through detailed histopathological and molecular analysis. Case presentation: We report the case of a 71-year-old female presenting with a gastric mass and anorexia, who was preoperatively misdiagnosed with gastrointestinal stromal tumor(GIST) based on clinical and imaging characteristics. Due to the massive tumor burden and anatomical complexity, the patient underwent an R0 resection combined with splenectomy. The final diagnosis of primary gastric UPS was established through an exclusionary process involving comprehensive histopathological, immunohistochemical (including negativity for CD117, CD34, DOG-1), and molecular analyses to rule out other tumors with specific lines of differentiation. Despite adjuvant doxorubicin chemotherapy, follow-up imaging revealed tumor recurrence two months postoperatively. Conclusion: This case underscores the highly aggressive biological behavior and dismal prognosis associated with primary gastric UPS. The rapid recurrence following multimodal therapy highlights the critical importance of considering UPS in the differential diagnosis of gastric soft tissue masses and emphasizes the urgent need for more effective, comprehensive therapeutic strategies.
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Mao et al. (2026) conducted a case report in Primary gastric undifferentiated pleomorphic sarcoma (n=1). R0 resection combined with splenectomy and adjuvant doxorubicin chemotherapy was evaluated on Tumor recurrence. In a 71-year-old female with primary gastric undifferentiated pleomorphic sarcoma, R0 resection and adjuvant doxorubicin chemotherapy resulted in tumor recurrence two months postoperatively.
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