Key result
Surgery plus adjuvant radiotherapy yields no one-year recurrence in a high-grade pleomorphic sarcoma case.
Why the study?
Undifferentiated pleomorphic sarcoma is an uncommon and aggressive soft tissue tumor requiring early detection and multidisciplinary treatment to improve outcomes.
Case Report (n=1)
No
This case report demonstrates the successful management of a large, high-grade undifferentiated pleomorphic sarcoma of the thigh with surgical excision and adjuvant radiotherapy, with no recurrence at one year.
Undifferentiated pleomorphic sarcoma (UPS) is an uncommon and aggressive soft tissue tumor primarily affecting older adults, often presenting as a rapidly enlarging, painless mass in the extremities or other deep-seated locations. This case involves a 55-year-old woman who experienced a rapidly progressive and painful swelling in her right thigh following trauma. Imaging studies identified a large, lobulated tumor in the adductor muscles, close to the femur and pubic ramus, with no bone involvement or evidence of distant metastasis. The patient underwent surgical excision, and histopathological analysis confirmed high-grade UPS, necessitating adjuvant radiotherapy due to narrow surgical margins. Follow-up evaluations, including MRI scans at six months and one year, revealed no signs of disease recurrence. The case underscores the critical role of early detection, multidisciplinary treatment planning, and rigorous postoperative monitoring to improve outcomes and reduce the risk of recurrence in patients with UPS.
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Munuswamy et al. (2024) conducted a case report in Undifferentiated Pleomorphic Sarcoma (n=1). Surgical excision and adjuvant radiotherapy was evaluated on Disease recurrence. Surgical excision followed by adjuvant radiotherapy for a high-grade undifferentiated pleomorphic sarcoma resulted in no signs of disease recurrence at one-year follow-up.
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