Undifferentiated Pleomorphic Sarcoma of Caecum

Undifferentiated pleomorphic sarcoma (UPS) is a diagnosis of exclusion. These tumours arising from the colon are a very rare entity, and only 21 cases have been reported so far in the literature. A 65-year-old male presented with abdominal pain and a vague abdominal mass in the right iliac fossa. On evaluation with contrast-enhanced computed tomography, the abdomen showed a heterogeneous mass arising from the right colon, resulting in colocolic intussusception. He underwent right hemicolectomy, and the final histopathology report was given as UPS arising from the caecum, FNCLCC Grade 3, pT1pN0, Stage 1. UPS is an aggressive disease with poor survival. The aetiology is largely unknown and the benefit of the addition of chemotherapy and radiotherapy to surgery needs further evaluation.