Serum Zinc, Chromium, and Iron Concentrations in Dogs with Lymphoma and Osteosarcoma

We compared serum concentrations of zinc, chromium, and iron in dogs with cancer to those of normal dogs. Dogs with lymphoma (n = 50) and osteosarcoma (n = 52) were evaluated. Dogs with lymphoma had significantly lower (P= .0028) mean serum zinc concentrations (mean ± SD; 1.0 ± 0.3 mg/L) when compared to normal dogs (1.2 ± 0.4 mg/L). Dogs with osteosarcoma also had lower mean serum zinc concentrations (1.1 ± 0.4 mg/L), but this difference was not significant (P= .075). Serum chromium concentrations were significantly lower in dogs with lymphoma (2.6 ± 2.6 μg/L, P= .0007) and osteosarcoma (2.4 ± 3.1 μg/L, P= .0001) compared to normal dogs (4.7 ± 2.8 μg/L). Serum iron concentrations and total iron-binding capacity were significantly lower in dogs with lymphoma (110.8 ± 56.7 μg/dL, P < .0001, and 236.6 ± 45.6 μg/dL, P < .0001, respectively) and osteosarcoma (99.6 ± 49.3 μg/dL, P < .0001, and 245.0 ± 43.8 μg/dL, P= .0011, respectively) when compared to normal dogs (175.1 ± 56.7 μg/dL and 277.1 ± 47.4 μg/dL). Mean ferritin concentration was significantly higher in dogs with lymphoma (1291.7 ± 63.0 μg/L) than in normal dogs (805.8 ± 291.1 μg/L, P < .0001) and dogs with osteosarcoma (826.5 ± 309.2 μg/L, P < .0001). Further investigation is needed to explore the clinical significance of these mineral abnormalities in dogs with cancer.