Key result
Mouse models of deep vein thrombosis, particularly the inferior vena cava stenosis model, are valuable tools for investigating the pathogenesis of venous thromboembolism.
Population
Mouse models of deep vein thrombosis
Design
Preclinical
Authors
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Requires side-branch control in animal IVC stenosis models; leaves open translation to human DVT research.
The inferior vena cava stenosis model closely mimics human deep vein thrombosis, but researchers must account for the significant impact of venous side branches on thrombus formation.
Schönfelder et al. (2016) conducted a review in Deep vein thrombosis. Mouse models of deep vein thrombosis, particularly the inferior vena cava stenosis model, are valuable tools for investigating the pathogenesis of venous thromboembolism.
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