Key result
Common NSAIDs and aspirin significantly reduced in vitro platelet aggregation to arachidonate (21-43% vs control 86%) and collagen (17-29% vs control 55%) (p < 0.01).
Why the study?
Do NSAIDs and aspirin have comparable antiplatelet effects in vitro?
Observational
Do NSAIDs and aspirin have comparable antiplatelet effects in vitro?
NSAIDs and aspirin demonstrate comparable in vitro antiplatelet effects, suggesting the need to reconsider the additional benefits of daily aspirin in patients on chronic NSAID therapy.
Answers are grounded in this paper and cite their sources.
NSAIDs show antiplatelet effects similar to aspirin in vitro; hypothesis-generating and should not yet change practice.
Antiplatelet effects of common analgesics were assessed in vitro. The Streck Platelet Aggregation Test Kit (Omaha, NE) was used to measure percent platelet aggregation in response to sodium arachidonate, collagen, adenosine diphosphate, and ristocetin in patients on various analgesics. In comparison with the control group, the response to arachidonate and collagen of ibuprofen (86% vs. 33% and 55% vs. 23%), naproxen (86% vs. 43% and 55% vs. 29%), indomethacin (86% vs. 26% and 55% vs. 17%), and aspirin (86 vs. 21% and 55 vs. 23%) all demonstrated a significant yet comparable reduction in platelet aggregation (p < 0.01). Because of the comparable antiplatelet effects of aspirin and NSAIDs, the additional benefits of daily aspirin in those patients on chronic and consistent NSAID therapy must be reconsidered.
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Cheng et al. (1997) conducted an observational in Patients on various analgesics. NSAIDs (ibuprofen, naproxen, indomethacin) and aspirin vs. Control group was evaluated on Percent platelet aggregation in response to sodium arachidonate and collagen (p=< 0.01). Common NSAIDs and aspirin significantly reduced in vitro platelet aggregation to arachidonate (21-43% vs control 86%) and collagen (17-29% vs control 55%) (p < 0.01).
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