Key result
Patients with acrocyanosis had a significantly lower LF/HF ratio compared to healthy controls (1.3 vs 1.5, p=0.041), suggesting systemic autonomic imbalance involving both sympathetic and parasympathetic systems.
Why the study?
Are heart rate variability indices altered in patients with acrocyanosis compared to healthy controls?
Cross-Sectional (n=46)
No
Are heart rate variability indices altered in patients with acrocyanosis compared to healthy controls?
Acrocyanosis is associated with systemic autonomic imbalance, involving disruption of both sympathetic and parasympathetic systems, rather than pure sympathetic over-activation.
Answers are grounded in this paper and cite their sources.
Altered HRV supports autonomic involvement in acrocyanosis; hypothesis-generating and should not yet change practice.
OBJECTIVE: To evaluate the autonomic activity of patients with acrocyanosis by using heart rate variability indices. MATERIAL AND METHODS: The study group consisted of 24 patients with acrocyanosis and the control group contained 22 sex- and age-matched healthy subjects. All subjects underwent 24-hour Holter monitoring. Among the heart rate variability (HRV) parameters, time-domain and frequency-domain indices were analysed. RESULTS: The time-domain indices of HRV indicating global autonomic functions were found to be increased, and indices indicating parasympathetic activity showed a significant decrease in the patient group. Power-spectral analysis of HRV revealed that the low frequency and high frequency power were higher in the patient group than in controls. However, the ratio of Low Frequency/High Frequency was found to be lower in the patient group than in controls. CONCLUSION: In acrocyanosis, both sympathetic and parasympathetic systems seem to be disrupted. Therefore, we may conclude that acrocyanosis may be resulted of systemic autonomic imbalance rather than pure sympathetic over-activation. Also, these results suggest that acrocyanosis is not a localised disorder; on the contrary, it is associated with various abnormalities of the systemic autonomic nervous system.
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Yılmaz et al. (2014) conducted a cross-sectional in Acrocyanosis (n=46). Acrocyanosis vs. Healthy controls was evaluated on LF/HF ratio (p=0.041). Patients with acrocyanosis had a significantly lower LF/HF ratio compared to healthy controls (1.3 vs 1.5, p=0.041), suggesting systemic autonomic imbalance involving both sympathetic and parasympathetic systems.
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