Key result
Obstructive CAD ≥50% was associated with lower Shannon entropy and 2ULV% and higher 0V% compared to CAD <50% and controls (p<0.05), indicating greater autonomic dysfunction.
Cross-Sectional (n=52)
p-value: p=<0.05
Patients with obstructive coronary artery disease exhibit greater autonomic dysfunction, characterized by lower heart rate variability complexity and increased sympathetic modulation, compared to those with non-obstructive disease or healthy controls.
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May signal greater autonomic dysfunction in obstructive CAD; hypothesis-generating and should not yet change practice or risk models.
Kunz et al. (2011) conducted a cross-sectional in Coronary artery disease (n=52). Obstructive CAD ≥50% vs. Obstructive CAD <50% and healthy controls was evaluated on Heart rate variability (Shannon entropy, 0V%, and 2ULV%) (p=<0.05). Obstructive CAD ≥50% was associated with lower Shannon entropy and 2ULV% and higher 0V% compared to CAD <50% and controls (p<0.05), indicating greater autonomic dysfunction.
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