Key result
Vincristine treatment in children with acute lymphoblastic leukemia significantly reduced heart rate variability compared to treatment phases without vincristine.
Why the study?
Does vincristine administration reduce heart rate variability in children with acute lymphoblastic leukemia?
Observational (n=9)
Does vincristine administration reduce heart rate variability in children with acute lymphoblastic leukemia?
Vincristine treatment in children with acute lymphoblastic leukemia induces transient autonomic cardioneuropathy, which can be effectively monitored by measuring heart rate variability.
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HRV reduction with vincristine in pediatric ALL may reflect autonomic effects; hypothesis-generating and should not yet change practice.
Hirvonen et al. (1989) conducted an observational in Acute lymphoblastic leukemia (n=9). Vincristine vs. Treatment phases without vincristine administration was evaluated on Heart rate variability. Vincristine treatment in children with acute lymphoblastic leukemia significantly reduced heart rate variability compared to treatment phases without vincristine.
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