Regiospecific Enzymatic Hydroxylations of Pyrazinecarboxylic Acid and a Practical Synthesis of 5-Chloropyrazine-2-Carboxylic Acid

All articles of this category Three different microorganisms capable of metabolizing pyridinecarboxylic acids were used for the regiospecific hydroxylation of all three ring carbon atoms of pyrazinecarboxylic acid to 3-hydroxy-5-hydroxy- or 6-hydroxypyrazine-2-carboxylic acid 1 . 5-Hydroxypyrazine-2-carboxylic acid was used for the preparation of 5-substituted pyrazine-2-carboxylic acids.