Key result
Halothane exposure caused significantly greater calibration drift in Transoxode TcPO2 electrodes compared to enflurane (5.40 vs -0.60 kPa; p<0.05).
Absolute Event Rate: 5.4% vs -0.6%
p-value: p=<0.05
Halothane, but not enflurane, directly affects the accuracy of the Transoxode TcPO2 electrode, causing significant calibration drift.
Halothane may impair TcPO2 electrode accuracy in animals; leaves open relevance to clinical transcutaneous monitoring.
The effects of halothane (0.5-2%) and enflurane (1-4%) on two Transoxode transcutaneous oxygen (TcPO2) electrodes (Hellige Servomed Oxymonitor SM.361 system) were serially tested in atmospheres of nitrogen, air and 50% nitrous oxide in oxygen. Both TcPO2 electrodes reduced and "read" halothane but no enflurane. Calibration drift was significantly greater (p less than 0.05) after electrode exposure to halothane; 5.40 s.e.m. 1.37 kPa vs enflurane; -0.60 s.e.m. 0.93 kPa. Halothane has a direct effect in rendering the Transoxode inaccurate, which is probably clinically less important than the indirect cardiovascularly medicated influence of both halothane and enflurane on TcPO2 levels. A reduction in the electrode polarisation voltage is recommended to obviate the direct effect of halothane on Transoxode performance.
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Downing et al. (1981) studied this question. Halothane vs. Enflurane was evaluated on Calibration drift (p=<0.05). Halothane exposure caused significantly greater calibration drift in Transoxode TcPO2 electrodes compared to enflurane (5.40 vs -0.60 kPa; p<0.05).
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