Key result
In isolated guinea pig hearts, halothane and enflurane significantly decreased left ventricular pressure by up to 34% (P<0.05), whereas isoflurane caused less depression and increased coronary flow.
Why the study?
Do halothane, enflurane, and isoflurane differentially affect oxygen supply and demand in isolated guinea pig hearts?
Population
47 isolated guinea pig hearts perfused at constant pressure
Comparison
Halothane, enflurane, or isoflurane vs Control (baseline measurements)
Design
Preclinical
Authors
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Isoflurane may preserve myocardial function better in this model; leaves open translation to human anesthetic selection.
Do halothane, enflurane, and isoflurane differentially affect oxygen supply and demand in isolated guinea pig hearts?
p-value: p=<0.05
In isolated guinea pig hearts, isoflurane causes less myocardial depression and increases coronary flow compared to halothane and enflurane.
Stowe et al. (1991) studied Myocardial and coronary vascular responses (n=47). Halothane, enflurane, and isoflurane vs. Control (baseline) was evaluated on Left ventricular pressure (LVP) (p=<0.05). In isolated guinea pig hearts, halothane and enflurane significantly decreased left ventricular pressure by up to 34% (P<0.05), whereas isoflurane caused less depression and increased coronary flow.
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