What is the clinical evidence from this study?

Study design: Other. Intervention: Halothane, enflurane, and isoflurane vs. Awake state. Primary outcome: Coronary blood flow autoregulation (slope of pressure-flow relationship and autoregulation index) (p=<.05).

What question did this study set out to answer?

This research aims to examine how halothane, enflurane, and isoflurane influence coronary blood flow autoregulation and vascular reserve in dogs.

January 1, 1988AnesthesiologyOpen Access

Effects of Halothane, Enflurane, and Isoflurane on Coronary Blood Flow Autoregulation and Coronary Vascular Reserve in the Canine Heart

Q: What are the key findings of this study?

Administration of 1.0 MAC enflurane, halothane, and isoflurane in dogs mildly disrupted coronary blood flow autoregulation compared to the awake state (P<0.05).

Q: What question did this study set out to answer?

This research aims to examine how halothane, enflurane, and isoflurane influence coronary blood flow autoregulation and vascular reserve in dogs.

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Key result

Administration of 1.0 MAC enflurane, halothane, and isoflurane in dogs mildly disrupted coronary blood flow autoregulation compared to the awake state (P<0.05).

Why the study?

Do volatile anesthetics (halothane, enflurane, isoflurane) affect coronary blood flow autoregulation and coronary vascular reserve in chronically instrumented dogs?

Population

Chronically instrumented dogs

Comparison

1.0 MAC halothane, enflurane, and isoflurane vs Awake state

Design

Preclinical

Authors

RHRobert F. HickeyRutgers, The State University of New Jersey PSPeter E. SybertUniversity of California, San Francisco EVEdward D. VerrierCross-Cutting Cardiology

Discussion

Member takes

Implication

Animal data on volatile anesthetics and CBF autoregulation; leaves open translation to human coronary physiology.

Key Points

This research aims to examine how halothane, enflurane, and isoflurane influence coronary blood flow autoregulation and vascular reserve in dogs.
Conducted experiments on chronically instrumented dogs, awake and under anesthesia with 1.0 MAC of halothane, enflurane, and isoflurane.
Measured coronary pressure-flow plots using a hydraulic occluder to vary coronary inflow pressure.
Quantified autoregulation using the slope of the pressure-flow relationship and the autoregulation index (ArI).
Halothane and isoflurane significantly increased the slope of autoregulation (slope values for halothane 0.414, isoflurane 0.795; P<0.05).
All anesthetics exhibited impaired autoregulation with ArI values indicating a decrease from 0.55 (awake) to below 0 for anesthetized states (halothane -0.08, enflurane -0.01, isoflurane -0.02; P<0.05).
Coronary vascular reserve and maximal coronary conductance were unchanged with the administration of these anesthetics.

Structured PICO

Do volatile anesthetics (halothane, enflurane, isoflurane) affect coronary blood flow autoregulation and coronary vascular reserve in chronically instrumented dogs?

Population

Chronically instrumented dogs studied awake and during administration of 1.0 MAC halothane, enflurane, and isoflurane.

Intervention

1.0 MAC halothane, enflurane, and isoflurane

Comparator

Awake state

Outcome

Coronary blood flow autoregulation (quantitated by the slope of the horizontal 'autoregulated' portion of the pressure-flow relationship and the autoregulation index [ArI]) and coronary vascular reservesurrogate

Main Result

p-value: p=<.05

Volatile anesthetics (halothane, enflurane, isoflurane) mildly disrupt coronary blood flow autoregulation in dogs without affecting maximal coronary blood flow or vascular reserve.

Cite This Study

Hickey et al. (1988) studied this question. Halothane, enflurane, and isoflurane vs. Awake state was evaluated on Coronary blood flow autoregulation (slope of pressure-flow relationship and autoregulation index) (p=<.05). Administration of 1.0 MAC enflurane, halothane, and isoflurane in dogs mildly disrupted coronary blood flow autoregulation compared to the awake state (P<0.05).

synapsesocial.com/papers/6a6c7d24a528af2d65c283cb https://doi.org/10.1097/00000542-198801000-00005

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Effects of Halothane, Enflurane, and Isoflurane on Coronary Blood Flow Autoregulation and Coronary Vascular Reserve in the Canine Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Effects of Halothane, Enflurane, and Isoflurane on Coronary Blood Flow Autoregulation and Coronary Vascular Reserve in the Canine Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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