Why the study?
Does desflurane have similar myocardial and coronary vascular effects compared to isoflurane in isolated guinea pig hearts?
Population
12 isolated guinea pig hearts perfused in a retrograde manner
Comparison
Desflurane injected directly into oxygenated… vs Isoflurane injected directly into oxygenated…
Design
Preclinical, Each heart was perfused randomly with these anesthetics
Authors
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Comparable effects in isolated hearts warrant caution extrapolating to patients; leaves open human translation.
Does desflurane have similar myocardial and coronary vascular effects compared to isoflurane in isolated guinea pig hearts?
Isoflurane and desflurane demonstrate similar concentration-dependent direct myocardial depressant effects in isolated guinea pig hearts.
Boban et al. (1992) studied this question.
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