January 1, 1996Anesthesia & Analgesia

Isoflurane-Induced Coronary Vasodilation Is Preserved in Reperfused Myocardium

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Population

14 open-chest dogs anesthetized with fentanyl and midazolam

Comparison

Isoflurane, acetylcholine, and sodium… vs Same interventions administered to normal…

Design

Preclinical

Authors

GCGeorge J. CrystalIllinois College JGJuozas GureviciusIllinois College MSM. Ramez SalemAdvocate Illinois Masonic Medical Center

Discussion

Member takes

Implication

Does not support changes in anesthetic practice; leaves open clinical translation while extending mechanistic evidence for NO-independent coronary vasodilation in animals.

Structured PICO

Population

14 open-chest dogs anesthetized with fentanyl and midazolam

Intervention

Isoflurane (1.4%, 1 MAC), acetylcholine (20 micrograms/min), and sodium nitroprusside (80 micrograms/min) administered to myocardium subjected to 15 min of ischemia and 30 min of reperfusion

Comparator

Same interventions administered to normal myocardium

Outcome

Steady-state changes in coronary blood flow (CBF)surrogate

Isoflurane-induced coronary vasodilation is preserved after brief ischemia-reperfusion, suggesting its mechanism is independent of the NO-cGMP pathway.

Cite This Study

Crystal et al. (1996) studied this question.

synapsesocial.com/papers/6a89100b46f665d0987606ec https://doi.org/10.1097/00000539-199601000-00005

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Implication

Does not support changes in anesthetic practice; leaves open clinical translation while extending mechanistic evidence for NO-independent coronary vasodilation in animals.

Isoflurane-Induced Coronary Vasodilation Is Preserved in Reperfused Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isoflurane-Induced Coronary Vasodilation Is Preserved in Reperfused Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider