Key result
Isoflurane caused a maldistribution of myocardial blood flow distal to critical stenosis but did not induce ischemia because it substantially reduced myocardial oxygen requirements.
Why the study?
Does isoflurane induce myocardial ischemia in dogs with critical coronary stenosis?
Population
12 open chest, anesthetized dogs with critical stenosis of the left circumflex coronary artery
Comparison
Isoflurane vs Left anterior descending coronary artery areas
Design
Preclinical
Authors
Loading...
May not induce ischemia despite maldistribution in this canine model; leaves open relevance to human perioperative coronary disease.
Does isoflurane induce myocardial ischemia in dogs with critical coronary stenosis?
Isoflurane causes maldistribution of coronary blood flow in the presence of critical stenosis but does not induce ischemia because it concurrently reduces myocardial oxygen requirements.
Takekawa et al. (1988) studied Critical stenosis of the left circumflex coronary artery (n=12). Isoflurane vs. Left anterior descending coronary artery (control) areas was evaluated on Myocardial blood flow, systolic wall thickening, regional oxygen extraction, and myocardial oxygen consumption. Isoflurane caused a maldistribution of myocardial blood flow distal to critical stenosis but did not induce ischemia because it substantially reduced myocardial oxygen requirements.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: