Why the study?
Does desflurane redistribute blood flow away from collateral-dependent myocardium via a coronary steal mechanism in a canine model of multivessel coronary artery disease?
Population
Chronically instrumented canine model with total occlusion of the left anterior descending coronary artery…
Comparison
Desflurane anesthesia with and without control… vs Conscious state (absence of desflurane anesthesia)
Design
Preclinical
Authors
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May support desflurane use under hemodynamic control in multivessel models; animal data leave human translation open.
Does desflurane redistribute blood flow away from collateral-dependent myocardium via a coronary steal mechanism in a canine model of multivessel coronary artery disease?
Desflurane does not cause coronary steal in a canine model of multivessel coronary artery disease when hemodynamics are controlled.
Hartman et al. (1991) studied this question.
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