Key result
Isoflurane-induced hypotension in dogs with critical coronary artery stenoses decreased segment length shortening by 70% (P<0.01) and caused regional myocardial dysfunction suggestive of ischemia.
Why the study?
Does isoflurane-induced hypotension cause regional myocardial dysfunction in dogs with critical coronary artery stenoses?
Population
12 open-chest dogs with critical coronary artery stenoses of the right and left anterior descending coronary…
Comparison
Isoflurane administration inducing hypotension… vs Baseline state prior to isoflurane…
Design
Preclinical
Authors
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May signal ischemic risk with isoflurane hypotension in critical stenoses; leaves open translation to human anesthesia.
Does isoflurane-induced hypotension cause regional myocardial dysfunction in dogs with critical coronary artery stenoses?
p-value: p=<0.01
Isoflurane-induced hypotension causes regional myocardial dysfunction suggestive of ischemia in the presence of critical coronary artery stenoses in a canine model.
Priebe et al. (1987) studied Critical coronary artery stenoses (n=12). Isoflurane-induced hypotension vs. Areas supplied by normal coronary arteries was evaluated on Segment length shortening in areas supplied by stenosed coronary arteries (p=<0.01). Isoflurane-induced hypotension in dogs with critical coronary artery stenoses decreased segment length shortening by 70% (P<0.01) and caused regional myocardial dysfunction suggestive of ischemia.
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