Key result
Isoflurane-induced hypotension caused more severe regional myocardial dysfunction than halothane, with substitution of halothane for isoflurane increasing stenosed LAD flow by 20% (P≤0.05).
Why the study?
Does isoflurane compared to halothane worsen regional myocardial dysfunction in dogs with critical coronary artery stenosis?
Population
8 open-chest dogs with a critical coronary artery stenosis of the left anterior descending coronary artery
Comparison
Isoflurane-induced hypotension to a mean aortic… vs Halothane-induced hypotension to a mean aortic…
Design
Preclinical
Authors
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Caution advised with isoflurane in coronary stenosis; animal data leave open human translation.
Does isoflurane compared to halothane worsen regional myocardial dysfunction in dogs with critical coronary artery stenosis?
p-value: p=≤0.05
In a canine model of critical coronary stenosis, isoflurane causes more severe regional myocardial dysfunction and ischemia than halothane at equivalent levels of hypotension.
Hans‐Joachim Priebe (1988) studied Critical coronary artery stenosis (n=8). Isoflurane vs. Halothane was evaluated on Global and regional left ventricular performance and coronary hemodynamics (p=≤0.05). Isoflurane-induced hypotension caused more severe regional myocardial dysfunction than halothane, with substitution of halothane for isoflurane increasing stenosed LAD flow by 20% (P≤0.05).
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