Key result
Blood platelets and their secretory products are intimately involved in atherosclerosis by affecting arterial wall cells, macrophage cholesterol accumulation, and foam cell formation.
This review highlights the mechanistic role of platelets in the development of atherosclerotic lesions, specifically through interactions with macrophages and LDL.
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Platelet-macrophage interactions in atherogenesis merit targeted mechanistic studies; leaves open whether secretion modulators alter human plaque progression.
Blood platelets have been shown to be intimately involved in atherosclerosis. Platelet secretory products can affect various functions and properties of arterial wall cells, such as the vasoconstriction of endothelial cells, smooth muscle cell proliferation and cholesterol metabolism in monocyte-derived macrophages. Macrophage cholesterol accumulation and foam cell formation, the hallmarks of the atherosclerotic process, can be significantly affected by blood platelets, either directly or via their effect on the interaction of cells with LDL or oxidized LDL.
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Michael Aviram (1992) conducted a review in Atherosclerosis. Blood platelets was evaluated. Blood platelets and their secretory products are intimately involved in atherosclerosis by affecting arterial wall cells, macrophage cholesterol accumulation, and foam cell formation.
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